CCMB was set up initially as a semi-autonomous Centre on April 1, 1977 with the Biochemistry Division of the then Regional Research Laboratory (presently, Indian Institute of Chemical Technology, IICT) Hyderabad forming its nucleus and Dr P M Bhargava heading the new Centre. Comparative epigenomic analysis across multiple genes presents a bottleneck for bench biologists working with NGS data. 115 (13) 2701-2712. Non-adhesive culture conditions established by suspending cells in methylcellulose containi...The tissues of a multicellular animal are composed of diverse cell types arranged in a precisely organized pattern. (DOC)Skeletal muscle stem cells, satellite cells, are normally quiescent but become activated upon muscle injury. Multiple regulatory elements, best defined in Drosophila melanogaster, ensure that Hox expression patterns follow the spatial and temporal colinearity reflected in their tight genomic organiz...Small non-coding RNAs such as miRNAs, piRNAs and endo-siRNAs fine-tune gene expression through post-transcriptional regulation, A partial list of the ∼1100 quiescence-induced genes is presented. 1978. In uninjured tissues, ASCs exist in a non-proliferating, reversibly cell cycle-arrested state known as quiescence or G0. Recruitment of resident satellite cells may be a useful strategy for treatment of muscle disorders, but little is known about gene expression in quiescent human satellite cells or the mechanisms involved in their early activation.
profiled small non-coding RNAs in Hydra magnipapillata and investigated changes in small RNA expr...Epigenetic modifications play a crucial role in developmental gene regulation. Department: Cell Biology and Development Research Area (CCMB) Overview. In almost all higher eukaryotes, the oocyte provides n...Epigenetic modifications play a crucial role in developmental gene regulation. During a conference in her first year, Dhawan was offered a scholarship by an Indian geneticist working in Canada to join his lab. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent mus...Hedgehog (Hh) is a secreted morphogen that elicits differentiation and patterning in developing tissues. Her research focuses on skeletal muscle regeneration and the contribution of quiescence or dormancy to adult stem cell function.
Department: Cell Biology and Development Research Area (CCMB) Overview. Stem Cells in Postnatal Myogenesis: Molecular Mechanisms of Satellite Cell Quiescence, Activation and Replenishment. Interestingly, a close analysis of the Saccharomyces cerevisiae literature leads to an appreciation of how much yeast bi...Quiescent stem cells contribute to tissue homeostasis and repair in adult mammals.
Cell. We have previously shown that abolishing adhesive interactions by suspension culture results in G(0) arrest of myoblasts. Quiescence is reversed during damage-induced regeneration and re-established after regeneration. The objectives of the Centre are to conduct high quality basic research and training in frontier areas of modern biology, and promote centralised national facilities for new and modern techniques in the inter-disciplinary areas of biology.CCMB was set up initially as a semi-autonomous Centre on April 1, 1977 with the Biochemistry Division of the then Regional Research Laboratory (presently, Indian Institute of Chemical Technology, IICT) Hyderabad forming its nucleus and Dr P M Bhargava heading the new Centre.
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